diff --git a/api/src/org/labkey/api/data/NameGenerator.java b/api/src/org/labkey/api/data/NameGenerator.java
index f2dbaeb97ae..13f4b740ccd 100644
--- a/api/src/org/labkey/api/data/NameGenerator.java
+++ b/api/src/org/labkey/api/data/NameGenerator.java
@@ -51,6 +51,7 @@
 import org.labkey.api.util.StringExpressionFactory;
 import org.labkey.api.util.StringExpressionFactory.AbstractStringExpression.NullValueBehavior;
 import org.labkey.api.util.StringExpressionFactory.FieldKeyStringExpression;
+import org.labkey.api.util.StringUtilsLabKey;
 import org.labkey.api.util.SubstitutionFormat;
 
 import java.io.IOException;
@@ -78,6 +79,7 @@
 import java.util.stream.Stream;
 
 import static org.labkey.api.exp.api.ExpMaterial.ALIQUOTED_FROM_INPUT;
+import static org.labkey.api.exp.api.ExpMaterial.ALIQUOTED_FROM_INPUT_LABEL;
 import static org.labkey.api.exp.api.ExpRunItem.INPUT_PARENT;
 import static org.labkey.api.exp.api.ExperimentJSONConverter.DATA_INPUTS;
 import static org.labkey.api.exp.api.ExperimentJSONConverter.MATERIAL_INPUTS;
@@ -739,6 +741,15 @@ public static Stream<String> parentNames(Object value, String parentColName, TSV
             if (StringUtils.isEmpty((valueStr).trim()))
                 return Stream.empty();
 
+            // GitHub Issue 827: Cannot aliquot samples where parent sample has a comma in the name AND the aliquot naming pattern references ancestor lineage
+            if (ALIQUOTED_FROM_INPUT.equalsIgnoreCase(parentColName) || ALIQUOTED_FROM_INPUT_LABEL.equalsIgnoreCase(parentColName))
+            {
+                boolean isQuoted = (valueStr.contains(",") || valueStr.contains("\n") || valueStr.contains("\r")) && (valueStr.startsWith("\"") && valueStr.endsWith("\""));
+                if (isQuoted)
+                    valueStr = StringUtilsLabKey.unquoteString(valueStr).trim();
+                return Stream.of(valueStr);
+            }
+
             // Issue 44841: The names of the parents may include commas, so we parse the set of parent names
             // using TabLoader instead of just splitting on the comma.
             boolean likelyAlreadyQuoted = valueStr.contains(",") || valueStr.contains("\n") || valueStr.contains("\r") || (valueStr.startsWith("\"") && valueStr.endsWith("\""));