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<!doctype html>
<html lang="en">
<head>
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<title>Model Bricks</title>
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<body data-spy="scroll" data-target="#navbar-menu" data-offset="50">
<nav id="navbar-menu" class="navbar fixed-top navbar-expand-lg navbar-dark">
<a class="navbar-brand" href="#">Model Bricks</a>
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<div id="one" class="banner-area">
<div class="intro-text container">
<h1 class="banner-area-headline">Model Bricks: small well-annoted modules used to build annotated, reusable models</h1>
<h3> Key features of ModelBricks include reliance on a commonly used standard language (SBML),
rule-based specification describing species as a collection of uniquely identifiable molecules,
association with model specific numerical parameters, and more common annotations.</h3>
</div>
</div>
<div id="three" class="dark-theme container-fluid section">
<div class="intro-box" id="one">
Complex molecular networks often can be constructed from simpler modules that we call bricks.
The adaptive behaviour of living cells is shown to be represented as a combination of
functional motifs that reproduce different patterns of cell response to a signal –
from simple linear and sigmoidal responses to more complex behaviours like toggle switches
and oscillators. The topology of these modules can be captured in graphical form and
represented as a wiring diagram in SBGN. However, to understand why these models work
the way they do, one must develop a precise mathematical description of molecular circuitry
and describe it in a different type of multiplex brick, that we call an executable brick
or a model brick.
</div>
<br><br>
<div id="browse" class="intro-box" >ModelBricks Repository (click to expand):</p>
<button type="button" class="collapsible">Generic Signal Response</button>
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<ul class="ml-md-auto nav nav-pills navbar-nav">
<li class="nav-item"><a class="nav-link" href=CM_PM12648679_MB1>Protein Synthesis and Degradation</a></li>
<li class="nav-item"><a class="nav-link" href=CM_PM12648679_MB6>Mutual activation</a></li>
<li class="nav-item"><a class="nav-link" href=CM_PM12648679_MB8>Negative feedback: homeostasis</a></li>
<li class="nav-item"><a class="nav-link" href=modelbrickslist_test>More...</a></li>
<ul>
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<button type="button" class="collapsible">Cell Cycle</button>
<div class="content">
<ul>
<li class="nav-item"><a class="nav-link" href=CM_PM1833774>Mitotic Oscillator</a></li>
<li>Bla-bla.</li>
<li>More...</li>
<ul>
</div>
<button type="button" class="collapsible">G-proteins</button>
<div class="content">
<ul>
<li>Bla-bla.</li>
<li>Bla-bla.</li>
<li>More...</li>
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